Figure 1: Schematic illustration of AFM-based single-molecule nanomechanical haplotyping with DNA origami shape IDs. | Nature Communications

Figure 1: Schematic illustration of AFM-based single-molecule nanomechanical haplotyping with DNA origami shape IDs.

From: DNA origami-based shape IDs for single-molecule nanomechanical genotyping

Figure 1

(a,b) Diploid genomic DNA extracted from genetic samples, which was site-specifically labeled with ‘multi-colour’ shape IDs. The two alleles of each SNP are labeled with different shape IDs. (c) Origami shape IDs serve as ‘magnifying lens’ to translate individual SNPs to origami nanostructures of several tens of nanometers. Consequently, the haplotype of this genomic DNA can be directly imaged under AFM. (d) Design and AFM images of sixteen shape IDs using DNA origami decorated with or without STV. Scale bar, 100 nm.

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