Figure 3: NEDD4 is required for glucose-induced H3 K9 acetylation at TSS and enhancers.
From: H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis
NEDD4 knockdown impaired glucose-induced genome-wide H3 K9 acetylation at TSS and enhancer regions. ChIP-seq was performed for control and NEDD4 knockdown Hep3B cells before or after adding-back of glucose for 3 h. Shown were global H3 K9ac profiles at TSS (a), Venn diagram of genes with differential H3 K9ac peaks at TSS under glucose treatment and NEDD4 knockdown condition (b,c), and global H3 K9ac profiles at known enhancers (d). See experimental procedures for details.
