Table 1 Summary results for newly discovered loci associated with renal cell carcinoma.

From: Genome-wide association study identifies multiple risk loci for renal cell carcinoma

Locus

SNP *

Closest gene

Position (base pairs)

A/a †

MAF ‡

Statistics

Discovery (10,784 cases; 20,406 controls)

Replication (3,182 cases; 6,301 controls)

Combined (13,966 cases; 26,707 controls)

1p32.3

rs4381241

FAF1

50907438

T/C

0.44

OR (95% CI)

1.11 (1.07–1.15)

1.11 (1.03–1.20)

1.11 (1.07–1.15)

      

P

1.1 × 10−8

8.7 × 10−3

3.1 × 10−10

      

I 2

17%

0%

0%

3p22.1

rs67311347

 

40533243

G/A

0.31

OR (95% CI)

0.89 (0.86–0.93)

0.94 (0.88–1.01)

0.90 (0.87–0.94)

      

P

4.7 × 10−8

8.8 × 10−2

2.5 × 10−8

      

I 2

0%

56%

20%

3q26.2

rs10936602

LRRIQ4

169536637

T/C

0.27

OR (95% CI)

0.90 (0.86–0.94)

0.91 (0.85–0.98)

0.90 (0.87–0.93)

      

P

2.7 × 10−7

9.7 × 10−3

8.8 × 10−9

      

I 2

0%

48%

11%

8p21.3

rs2241261

RHOBTB2/TNFRSF10B

22876739

C/T

0.51

OR (95% CI)

1.10 (1.06–1.14)

1.10 (1.03–1.17)

1.10 (1.06–1.13)

      

P

3.5 × 10−7

2.0 × 10−2

5.8 × 10−9

      

I 2

3%

58%

21%

10q24.33-q25.1

rs11813268

OBFC1

105682296

C/T

0.16

OR (95% CI)

1.13 (1.08–1.19)

1.10 (1.01–1.19)

1.12 (1.07–1.17)

      

P

5.1 × 10−7

2.1 × 10−2

3.9 × 10−8

      

I 2

32%

0%

0%

11q22.3

rs74911261

KDELC2

108357137

G/A

0.02

OR (95% CI)

1.42 (1.26–1.61)

1.38 (1.12–1.69)

1.41 (1.27—1.57)

      

P

2.1 × 10−8

2.6 × 10−3

2.1 × 10−10

      

I 2

0%

0%

0%

 

rs1800057

ATM

108143456

C/G

0.02

OR (95% CI)

1.40 (1.24–1.59)

1.30 (1.04–1.62)

1.38 (1.23–1.53)

      

P

1.1 × 10−7

2.2 × 10−2

9.0 × 10−9

      

I 2

14%

0%

0%

14q24.2

rs4903064

DPF3

73279420

T/C

0.23

OR (95% CI)

1.18 (1.13–1.23)

1.30 (1.21–1.39)

1.21 (1.16–1.25)

      

P

1.1 × 10−14

2.6 × 10−12

2.2 × 10−24

      

I 2

28%

0%

36%

  1. *SNP with lowest P value within locus. For 11q22.3, results shown for two non-synonymous SNPs in KDELC2 (rs74911261, Pro144Leu) and ATM (rs1800057, Pro1054Arg; r2=0.83 in CEU).
  2. †A, common allele; a, minor allele.
  3. ‡Minor allele frequency among all controls (n=26,707). Odds ratios (OR) are shown for the minor allele, assuming a log-additive (trend) SNP effect.
Back to article page