Figure 5: P-Rspo3 tumours are molecularly distinct from Apc-mutant tumours. | Nature Communications

Figure 5: P-Rspo3 tumours are molecularly distinct from Apc-mutant tumours.

From: R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine

Figure 5: P-Rspo3 tumours are molecularly distinct from Apc-mutant tumours.

(a) Graphs represent expression (RPKM value) of Sox17, Sox9 and Axin2 on WT, P-Rspo3 and Apc-deleted organoids (n≥4, bars represent mean values+/−s.d., **P<0.01, ***P<0.001, ****P<0.0001, two-sided t-test with Welch correction). (b) Immunohistochemical staining of Sox17, Sox9 and Axin2 on small intestinal sections from dox-treated CR8, Apc sgRNA and P-Rspo3 animals. Scale bars are labelled in the figure.

Back to article page