Figure 4: Comparative interaction summaries for K27 and K55 complexes with Ras.
From: Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange
Direct residue interactions in the two DARPin/Ras complexes are summarized for the comparison of DARPin K55/Ras (a) with K27/Ras (b). While some Ras residues participate in both DARPin interactions, namely Gln 25, Asp 38 and Ser 39, most of the participating Ras residues are unique to either the K55 or K27 interaction, suggesting very different overall binding modes in each case.
