Figure 6: Structures of EF-Tu mutants.
From: Energetics of activation of GTP hydrolysis on the ribosome
Predicted structures from MD simulations of the (a) His84Ala, (b,c) His84Arg and (d) His84Gln mutations. For arginine, two conformations are potentially possible in the reaction centre of the ribosomal complex and these correspond to the (b) g−g+tt and (c) g−tg−g− arginine sidechain rotamers. The glutamine mutation (d) is depicted in the state with a transient metaphosphate (partial bonds indicated with dotted lines). The view in all cases is essentially the same as in Fig. 3 with the same residues depicted.
