Figure 2: Pathologic abnormalities in the Neu1−/− hippocampus. | Nature Communications

Figure 2: Pathologic abnormalities in the Neu1−/− hippocampus.

From: Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosis

Figure 2

(a) haematoxylin and eosin staining demonstrated numerous eosinophilic bodies (arrows) in the CA3 region of the Neu1−/− brain (mice 5 months of age). Scale bar, 20 μm. (b) Methoxy-XO-4-stained amyloid deposits in Neu1−/− hippocampus. Scale bars, 100 μm (mice 5 months of age; scale bar, 50 μm for zoom in). (c) Z-stacks obtained from confocal images of Neu1−/−. Methoxy-XO4+ amyloid deposits were used to build a three-dimensional surface rendering. Scale, bar 250 μm. (d) In the Neu1−/− hippocampus, APP starts to accumulate intracellularly as early as 1 month of age, as revealed by IHC analysis with anti-APP N-terminal antibody (brown). (e) Amyloid deposits in 5-month-old Neu1−/− brain stained positive for APP (N-terminal antibody). (d,e) Scale bars, 20 μm.

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