Figure 7: Schematic model.

In the absence of Neu1, oversialylated APP is abnormally processed in lysosomes and the generated Aβ−peptide is released in the extracellular space via excessive lysosomal exocytosis.

In the absence of Neu1, oversialylated APP is abnormally processed in lysosomes and the generated Aβ−peptide is released in the extracellular space via excessive lysosomal exocytosis.