Figure 7: Interindividual variation in heterochromatic gene silencing through ADAR activity.
From: RNA editing regulates transposon-mediated heterochromatic gene silencing
(a) Representative examples (right) and percentages of categories of Hokmw/Hok+ PEV reporter expression observed in wild-type and dAdar auto-editing mutant backgrounds, n dAdarS=572, n dAdarLoxp=492 and n dAdarG=534. Scale bar, 150 μm. (b) Editing levels at 30 dADAR target adenosines, presented as the % editing in category 3 thorax tissue normalized to the mean editing in category 1 thorax tissue for each site. (c) Speculative model of the functional consequences of dADAR auto-editing on PEV reporter expression via differential modulation of the small RNA pathway. Error bars indicate s.e.m. *P<0.05, **P<0.005, ***P<0.0005, Mann–Whitney U-test.
