Figure 1: DG has more Aβ deposit and reactive astrocytes than the CA1 region in the 5xFAD mice. | Nature Communications

Figure 1: DG has more Aβ deposit and reactive astrocytes than the CA1 region in the 5xFAD mice.

From: Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer’s disease model

Figure 1

(a) Representative images showing more Aβ immunostaining (red) and reactive astrocytes (green) in the DG than in the CA1 region of 5xFAD mice. Blue is 4′,6-diamidino-2-phenylindole staining for the cell nucleus. (b) Quantified data showing increased Aβ-covered area, Aβ plaque size and GFAP-covered area in the DG compared with the CA1 region in 5xFAD mice. Bar values are shown as mean±s.e.m., n=11. Scale bar=50 μm (20 μm in enlarged images). **P<0.01; ***P<0.001; paired Student’s t-test.

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