Figure 1: Accumulation of SNPs and CNPs in the H. pylori genomes after re-infection of human hosts.

(Circle contents from outside to inside). Circle 1: Genomes of H. pylori strains BM012A (a) and BM013A (b) with the positions of IS607 (red), the cag PAI, the vacA gene and ticks every 100 kb. Circle 2: Distribution of non-coding (black), non-synonymous (red) and synonymous (blue) SNPs in the genomes of the output strains BM012B (168 SNPs) and BM013B (54 SNPs). Circle 3: Distribution of imported (orange) and translocated (green) DNA fragments in the genomes of the two output strains. syn SNP, synonymous SNP; non-syn SNP, non-synonymous SNP.