Table 1 Association evidence for five SNVs obtained in the exome sequencing and targeted sequencing stages through logistic regression (additive model).
From: Sequencing-based approach identified three new susceptibility loci for psoriasis
Chr | Gene of interest | Variant ID | Stage* | Allele | MAF | P -value | OR (95% CI) | Combined | ||
|---|---|---|---|---|---|---|---|---|---|---|
Cases | Controls | P -value | OR (95% CI) | |||||||
4q24 | NFKB1 | rs1020760 | i | G/C | 0.4351 | 0.4371 | 9.49 × 10−1 | 0.99 (0.95–1.24) | 2.19 × 10−8 | 1.12 (1.08–1.17) |
ii | G/C | 0.4634 | 0.4352 | 1.76 × 10−8 | 1.12 (1.02–1.26) | |||||
4q24 | NFKB1 | rs1609798 | i | T/C | 0.3675 | 0.3380 | 2.31 × 10−1 | 1.14 (0.84–1.14) | 9.87 × 10−8 | 1.12 (1.08–1.17) |
ii | T/C | 0.3698 | 0.3433 | 9.87 × 10−8 | 1.12 (1.08–1.17) | |||||
2q24 | IFIH1 | rs13431841 | i | A/G | 0.0625 | 0.1184 | 2.56 × 10−1 | 0.50 (0.15–1.70) | 2.96 × 10−9 | 0.83 (0.78–0.88) |
ii | A/G | 0.1021 | 0.1208 | 3.84 × 10−9 | 0.83 (0.78–0.88) | |||||
5q31.1-q33.1 | IL12B | rs2288831 | i | C/T | 0.3684 | 0.4324 | 1.68 × 10−2 | 0.77 (0.62–0.95) | 2.30 × 10−20 | 0.83 (0.80–0.86) |
ii | C/T | 0.3986 | 0.4434 | 3.11 × 10−19 | 0.83 (0.80–0.87) | |||||
5q15 | ERAP1 | rs27043 | i | A/G | 0.4681 | 0.4803 | 5.61 × 10−1 | 0.95 (0.81–1.12) | 6.50 × 10−12 | 0.87 (0.84–0.91) |
ii | A/G | 0.4635 | 0.4986 | 4.33 × 10−12 | 0.87 (0.83–0.90) | |||||
