Figure 4: Stathmin phosphorylation is essential for hippocampus-dependent memory. | Nature Communications

Figure 4: Stathmin phosphorylation is essential for hippocampus-dependent memory.

From: Learning-induced and stathmin-dependent changes in microtubule stability are critical for memory and disrupted in ageing

Figure 4

(a) Deficient long-term (24 h) contextual fear memory in Stat4A mice is rescued by dox. WT, n=14; Stat4A, n=15; Stat4A on dox, n=14. *P<0.05 versus WT mice (post-hoc comparison). (b) Normal short-term (0.5 h) memory in Stat4A mice. n=10 per group. (c) Cued fear memory is normal in Stat4A mice. n=14 per group. (d–g) Morris water maze. There was no difference in the visible platform task between the genotypes (d). In hidden platform, the latencies of Stat4A mice were slower than those of WT mice (e). In the reversal learning (transfer task), Stat4A mice showed longer latency to find the platform (f). The probe trial (g) shows normal spatial memory recall in Stat4A mice. n=10 for each group. *P<0.05. (h) Reduced spatial learning in Stat4A mice assessed in Barnes maze. n=11 for each group. *P<0.05. Data are expressed as mean±s.e.m.

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