Figure 5: Stathmin control of microtubule stability in the dentate gyrus is critical for contextual fear conditioning. | Nature Communications

Figure 5: Stathmin control of microtubule stability in the dentate gyrus is critical for contextual fear conditioning.

From: Learning-induced and stathmin-dependent changes in microtubule stability are critical for memory and disrupted in ageing

Figure 5

(a) AAV-mediated overexpression of Stat4A in the dentate gyrus (DG) detected by immunohistochemistry with anti-GFP antibody. Scale bar, 200 μm. (b,c) Immunoblot estimation of detyrosinated α-tubulin levels 0.5 h after training in the DG synaptosomal fraction of mice injected with AAV-GFP or AAV-Stat4A-IRES-GFP. N, naive. n=5–7 per group (pooled tissues from three to four mice per sample). *P<0.05 versus naive mice (Student’s t-test). (d) AAV-mediated overexpression of Stat4A reduces contextual fear memory. n=11–12 per group. *P<0.01 (Student’s t-test). Data are expressed as mean±s.e.m.

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