Figure 6: Role of learning-induced microtubule instability in memory. | Nature Communications

Figure 6: Role of learning-induced microtubule instability in memory.

From: Learning-induced and stathmin-dependent changes in microtubule stability are critical for memory and disrupted in ageing

Figure 6

(a) Mice injected with paclitaxel immediately following training show reduced freezing. Vehicle, n=11; Paclitaxel, n=12. *P<0.05 (Student’s t-test). (b) stathmin−/− mice show deficit in microtubule destability and stability at 0.5 and 8 h after training. n=6 per group (pooled tissues from three to four mice per sample). N, naive. *P<0.05 versus naive in corresponding genotype (post-hoc comparison). (c) stathmin−/− mice show reduced long-term (24 h) contextual fear memory. n=12 per group. *P<0.01 (Student’s t-test).

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