Figure 8: Stathmin controls learning-induced dendritic transport of GluA2 by modulating binding of motor protein KIF5 to microtubules. | Nature Communications

Figure 8: Stathmin controls learning-induced dendritic transport of GluA2 by modulating binding of motor protein KIF5 to microtubules.

From: Learning-induced and stathmin-dependent changes in microtubule stability are critical for memory and disrupted in ageing

Figure 8

Co-immunoprecipitation reveals deficiency in protein binding between GluA2 and α-tubulin (a), KIF5 and α-tubulin (b), and GluA2 and KIF5 (c) in stathmin−/− mice. N, naive. n=4 per group (pooled tissues from two to three mice per sample). *P<0.05 (post-hoc comparison). (d) Scheme of the experimental design and TAT-GluA23Y peptide (TAT-Pep.) injection schedule is shown. (e) Blocking GluA2 endocytosis by intra-hippocampal injection of TAT-GluA23Y peptide has no effect in WT mice, but rescues contextual fear memory in stathmin−/− mice. n=12–13. *P<0.05 versus mice given TAT-control peptide (post-hoc comparison). (f) Rescue of contextual fear memory by TAT-GluA23Y peptide in WT mice injected with AAV-Stat4A-IRES-GFP. n=10–12. *P<0.05 (post-hoc comparison). Data are expressed as mean±s.e.m.

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