Figure 4: Chronic hyperglycaemia reversibly alters β-cell ultrastructure.
From: Reversible changes in pancreatic islet structure and function produced by elevated blood glucose
Representative electron micrographs of pancreatic sections from control mice (a), βV59M mice exposed to hyperglycaemia for 4 weeks (b), βV59M mice treated with insulin for 4 weeks (c) and βV59M mice that were hyperglycaemic for 4 weeks and then treated with glibenclamide for 4 weeks (d). Scale bar, 2 μm (refers to all panels). Images are representative of: a, 9 mice/9 islets/150 β-cells; b, 3 mice/9 islets/134 β-cells; c, 2 mice/3 islets/100 β-cells; d, 3 mice/3 islets/105 β-cells.
