Figure 6: Dynamics of shaft and spine gephyrin clusters in patDp/+ mice and NLG R451C mice.
From: Enhanced synapse remodelling as a common phenotype in mouse models of autism
(a) An example of dynamic gephyrin-GFP clusters (grey in middle panels, green in right panels) on the dendritic shaft. Loss of a gephyhrin-GFP cluster was detected (arrowhead). (b) An example of dynamic gephyrin-GFP clusters (grey in middle panels, green in right panels) on dendritic spines. Gain of a gephyhrin-GFP cluster was detected (arrowhead). (c) Density of gephyrin clusters on dendritic shafts in the SSC of wild-type and patDp/+ mice. (d) Gain and loss of gephyrin clusters on dendritic shafts in the SSC of wild-type and patDp/+ mice. (e) Gain and loss of gephyrin clusters on dendritic spines in the SSC of wild-type and patDp/+ mice. (f) Density of gephyrin clusters on dendritic shafts in the SSC of wild-type and NLG R451C mice. (g) Gain and loss of gephyrin clusters on dendritic shafts in the SSC of wild-type and NLG R451C mice. (h) Gain and loss of gephyrin clusters on dendritic spines in the SSC of wild-type and NLG R451C mice. Data are presented as mean±s.e.m. *P<0.05, Student’s t-test. Scale bars, 3 μm. Refer to the Supplementary Tables 2 and 3 for the number of animals in each group.
