Figure 5: NSCLC subtype-specific prognostic impact of metabolism proteome clusters C10 and C15. | Nature Communications

Figure 5: NSCLC subtype-specific prognostic impact of metabolism proteome clusters C10 and C15.

From: Integrated Omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact

Figure 5

The dendrogram of metabolism proteins (Fig. 4c) was systematically tested for association of DNA alterations in the encoding genes. Kaplan–Meier plots relate survival of patients with (dotted line) and without (straight line) alterations. DNA alterations in genes encoding cluster C10 were found in 11% of lung SCC and associated with better overall survival (blue). DNA alterations associated with cluster C15 were found in 22% of lung ADC, and were associated with worse outcome (red). The total number of patients is shown in parenthesis. Patient data were obtained through cBioPortal. See also Supplementary Data 3 and 4. MPCI, metabolism-proteome cluster index, as in Table 3.

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