Figure 1: Location of the studied fALS mutations of SOD1.
From: In-cell NMR reveals potential precursor of toxic species from SOD1 fALS mutants
The backbone positions of the studied fALS-linked mutations (magenta spheres) are displayed on the solution NMR structure of Cu(I),Zn-SOD1SS (PDB code: 1L3N), shown in white cartoon. With the exception of G85R, all the mutations reside far from the metal binding sites (shown as sticks). Copper and zinc ions are shown as orange and grey spheres, respectively. The side chains of Cys57 and Cys146 are also shown as yellow sticks.
