Figure 1: Metabolites’ associations with longevity and morbidity profiles.
From: Distinct metabolomic signatures are associated with longevity in humans
Mean and s.e.m. values of selected log metabolite values are shown by morbidity profile in the first-stage study sample (N=647). Among individuals who lived to age ⩾80 years, log aconitate (P=0.004), log-isocitrate (P=0.0005) and log malate (P=0.012) levels were significantly higher in those who ever developed cardiovascular disease compared with those who remained free of cardiovascular disease (a,c,e). These metabolites did not differentiate between individuals based on cancer morbidity (b,d,f). Comparisons were performed using t-tests.
