Figure 3: Metabolite pathways observed in association with human longevity.
From: Distinct metabolomic signatures are associated with longevity in humans
Aggregate results of the current study suggest that higher circulating levels of certain citric acid cycle intermediates (isocitrate, aconitate and malate) are associated with shortened lifespan by increasing cardiovascular risk, whereas increased taurocholate is related to shorter lifespan independent of any concurrent associations with major morbid disease (a). Metabolomic pathway topology analysis highlights the potential importance of distinct pathways that comprise the human metabolome that are represented by metabolites associated with longevity in the current study (b).
