Table 2 Metabolites associated with attaining longevity defined as 80 years of age (first-stage sample: N=647).

From: Distinct metabolomic signatures are associated with longevity in humans

Profiling method

Metabolite*

Age- and sex adjusted

Multivariable-adjusted †

  

OR (95% CI)

P value

OR (95% CI)

P value

Polar, positively charged

Cotinine

0.65 (0.53–0.79)

1.1E−05

0.79 (0.56–1.13)

0.20

 

Histidine

1.33 (1.10–1.61)

0.004

1.28 (1.05–1.56)

0.02

 

Lysine

1.36 (1.10–1.68)

0.004

1.32 (1.06–1.65)

0.01

 

Threonine

1.34 (1.09–1.64)

0.006

1.30 (1.04–1.62)

0.02

Polar, negatively charged

Aconitate

0.74 (0.60–0.92)

0.007

0.73 (0.58–0.92)

0.008

 

β-hydroxybutyrate

0.71 (0.57–0.89)

0.003

0.73 (0.58–0.92)

0.008

 

Isocitrate

0.65 (0.52–0.82)

2.5E−04

0.63 (0.49–0.81)

3.9E−04

 

Malate

0.75 (0.62–0.91)

0.003

0.75 (0.61–0.92)

0.005

 

Taurocholate

0.65 (0.50–0.83)

5.0E−04

0.63 (0.48–0.83)

7.4E−04

 

Uridine

1.41 (1.14–1.76)

0.002

1.27 (1.01–1.59)

0.04

Lipid

LPC 22:6

1.54 (1.23–1.94)

2.1E−04

1.41 (1.11–1.79)

0.005

 

PC 38:6

1.62 (1.29–2.05)

4.6E−05

1.52 (1.18–1.95)

0.001

  1. CI, confidence interval; LPC, lysophosphatidylcholine; OR, odds ratio; PC, phosphatidylcholine.
  2. *Metabolites were natural log transformed and standardized (mean=0, s.d.=1).
  3. †All logistic regression analyses adjusted for age and sex; multivariable-adjusted models additionally adjusted for body mass index, systolic blood pressure, antihypertensive treatment, diabetes, smoking status, total cholesterol, high-density lipoprotein cholesterol and log triglycerides.
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