Table 4 Metabolites associated with incident cardiovascular disease (second-stage sample: N=2,327).

From: Distinct metabolomic signatures are associated with longevity in humans

Profiling method

Metabolite*

Age- and sex adjusted

Multivariable-adjusted †

  

HR (95% CI)

P value

HR (95% CI)

P value

Polar, positively charged

Cotinine

1.20 (1.08–1.32)

0.0004

1.14 (0.95–1.36)

0.16

 

Histidine

0.87 (0.80–0.96)

0.005

0.88 (0.80–0.97)

0.01

 

Lysine

0.97 (0.88–1.07)

0.55

0.95 (0.85–1.05)

0.31

 

Threonine

0.91 (0.82–1.01)

0.07

0.94 (0.85–1.04)

0.20

Polar, negatively charged

Aconitate

1.18 (1.05–1.33)

0.005

1.10 (0.97–1.24)

0.14

 

β-Hydroxybutyrate

1.10 (0.99–1.23)

0.07

1.10 (0.98–1.23)

0.10

 

Isocitrate

1.35 (1.20–1.52)

3.0E−07

1.22 (1.08–1.38)

0.002

 

Malate

1.18 (1.05–1.32)

0.004

1.16 (1.04–1.30)

0.009

 

Taurocholate

1.06 (0.93–1.20)

0.40

1.03 (0.90–1.17)

0.69

 

Uridine

0.89 (0.80–0.995)

0.04

0.93 (0.83–1.04)

0.22

Lipid

LPC22:6

0.92 (0.82–1.02)

0.09

0.96 (0.87–1.07)

0.50

 

PC38:6

0.93 (0.83–1.04)

0.18

0.95 (0.84–1.06)

0.34

  1. CI, confidence interval; HR, hazards ratio; LPC, lysophosphatidylcholine; PC, phosphatidylcholine.
  2. No. of events per persons at risk was 358/2,327 for the sample with polar positive analyte data, 326/1,937 for the sample with polar negative analyte data and 326/1,944 for the sample with lipid data.
  3. *Metabolites were natural log transformed and standardized (mean=0, s.d.=1).
  4. †All analyses adjusted for age and sex; multivariable-adjusted models additionally adjusted for body mass index, systolic blood pressure, antihypertensive treatment, diabetes, smoking status and total/high-density lipoprotein cholesterol.
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