Table 1 Individual set-unique burden (ISUB) analysis.

From: Genome-wide burden of deleterious coding variants increased in schizophrenia

Variant type

Disease Status

Number of SNVs

Individual burden score (mean/median/s.d.)

P value

NS

Case

16,262

8.73/ 7.26/ 9.65

0.033

 

Control

12,964

7.27/ 6.56/ 5.62

 

DEL

Case

6,424

7.54/ 6.29/ 8.18

0.018

 

Control

5,130

6.23/ 5.58/ 4.78

 

NS—DEL

Case

9,838

1.18/ 0.94/ 1.62

0.492

 

Control

7,834

1.04/ 0.85/ 1.07

 
  1. The number of set-unique SNVs and mean individual burden score for all non-synonymous variants (NS) as well as the two complementary subsets of only deleterious (DEL) variants as well as non-synonymous variants not predicted to be deleterious (NS-DEL). Empirical P-values are estimated by permutation (10,000 permutations) of the phenotypes (cases n=1,002, controls n=931) based on Wilcoxon Rank Sum Test statistics. See also Supplementary Fig. 1 and Supplementary Table 1. Values in bold withstands correction for multiple testing (Supplementary Methods).
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