Figure 1: HCV IRES bound to human ribosome.
From: Cryo-EM structure of Hepatitis C virus IRES bound to the human ribosome at 3.9-Å resolution
(a) Secondary structure diagram of the HCV IRES. The various domains are indicated by different colours and roman numbers. Canonical base pairs are marked by lines and non-standard base pairs by circles. Interactions of the IRES with ribosomal proteins are highlighted in orange, interactions with the 18S rRNA in dark yellow. Bases not built in our structure are indicated in grey, the start codon is indicated by a black box. (b) Cartoon representation of the HCV IRES secondary structure. The interaction sites of the different domains are indicated. (c) EM density of 80S–HCV IRES complex showing that the HCV IRES does not contact the 60S subunit. The 40S is coloured in yellow, the 60S in blue and the HCV IRES in pink. (d) Structure of the HCV IRES bound to the human 40S. Views from the intersubunit side (left) and the solvent side (right).
