Table 1 Physiological variables in S1pr2+/+ and S1pr2−/− mice.

From: Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke

Time points

Parameters

S1pr2 +/+

S1pr2 −/−

10 min before MCAO

Arterial O2 saturation (SpO2, %)

97.0±0.6

98.4±0.2

 

Heart rate (b.p.m.)

493.0±9.2

520.9±31

 

Pulse distention (μm)

13.4±4.5

18.3±8.3

 

Respiratory rate (br.p.m.)

110.1±11.1

109.1±5.1

10 min after MCAO

Arterial O2 saturation (SpO2, %

97.0±0.6

98.2±0.3

 

Heart rate (b.p.m.)

531.3±13.8

524±13.5

 

Pulse distention (μm)

19.3±5.8

15.7±3.7

 

Respiratory Rate (br.p.m.)

104.5±3.5

115.7±8.3

10 min after reperfusion

Arterial O2 saturation (SpO2, %)

96.8±1.1

98.1±0.2

 

Heart rate (b.p.m.)

496.6±14.76

525.6±11

 

Pulse distention (μm)

16.6±1

13.0±3.3

 

Respiratory rate (br.p.m.)

107.8±5.8

112.2±5.2

  1. bpm, beats per minute; br.p.m., breaths per minute; MCAO, middle cerebral artery occlusion.
  2. Pulse distention is a surrogate for pulse pressure (pulse pressure=systolic pressure−diastolic pressure). JTE013 (30 mg kg−1) or vehicle was administered after reperfusion. No significant differences were observed in the physiological parameters (arterial O2 saturation, heart rate, pulse distention and respiratory rate) between wild-type and S1pr2−/− mice, before, during or after MCAO.
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