Figure 4: Restoration of plasma TG-hydrolysis activities improves Rheb-induced hypertriglyceridemia. | Nature Communications

Figure 4: Restoration of plasma TG-hydrolysis activities improves Rheb-induced hypertriglyceridemia.

From: A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals

Figure 4

(a,b) Rheb (black bars) or LacZ (white bars) adenovirus was administered to C57BL/6 mice. Vehicle (Veh) or dextran sodium sulfate (DSS) was intravenously administered to standard chow-fed C57BL/6 mice 5 days after adenoviral administration. Plasma TG-hydrolysis activities (a) were measured and serum TG levels (b) were examined 30 min after injection of these agents (a; n=6–7, b; n=3–4). (c,d) Mixed adenoviruses, that is, double-dose LacZ-adenovirus (ZZ), LacZ plus Rheb (ZR) and Rheb plus LPL (RL) adenoviruses, were administered to C57BL/6 mice. Plasma TG-hydrolysis activities (c) were measured, and serum TG levels (d) were examined 5 days after adenoviral administration (c; n=5–6, d; n=5–6). Data are presented as means±s.d. *P<0.05, **P<0.01 by the unpaired t-test. NS, not significant.

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