Figure 8: Upregulation of plasma TG-hydrolysis activities relieves obesity-related hypertriglyceridemia. | Nature Communications

Figure 8: Upregulation of plasma TG-hydrolysis activities relieves obesity-related hypertriglyceridemia.

From: A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals

Figure 8

(a–c) Vehicle (Veh) or dextran sodium sulfate (DSS) was intravenously administered to standard chow-fed KK and KK-Ay mice. Plasma TG-hydrolysis activities (a) and LPL activities (b) were measured, and serum TG levels (c) were examined 30 min after the injection of these agents (a; n=7–8, b; n=7–8, c; n=5–7). (d–f) LPL (black bars) or LacZ (white bars) adenovirus was administered to KK and KK-Ay mice. Plasma TG-hydrolysis activities (d) and LPL activities (e) were measured, and serum TG levels (f) were examined 5 days after adenoviral administration (d; n=5–8, e; n=5–8, f; n=6–8). Data are presented as means±s.d. *P<0.05, **P<0.01 by the unpaired t-test. NS, not significant.

Back to article page