Figure 9: Blockage of hepatic vagus suppresses the development of hypertriglyceridemia associated with obesity. | Nature Communications

Figure 9: Blockage of hepatic vagus suppresses the development of hypertriglyceridemia associated with obesity.

From: A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals

Figure 9

(a,c,e) Standard chow-fed C57BL/6 and ob/ob mice were subjected to sham operation (Sham) or HV. (a) Immunoblotting of liver extracts from these sham- and HV-mice with anti-phospho-mTOR, mTOR, phospho-p70-S6K, p70-S6K, phospho-S6 and S6 antibodies. Serum TG levels (c) and LPL mRNA expressions in WAT (e) were examined on day 14 after these operations (c; n=15–19, e; n=7–9). (b,d,f) Standard chow-fed KK and KK-Ay mice were subjected to sham operation (Sham) or HV. (b) Immunoblotting of liver extracts from these sham- and HV-mice with anti-phospho-mTOR, mTOR, phospho-p70-S6K, p70-S6K, phospho-S6 and S6 antibodies. Serum TG levels (d) and LPL mRNA expressions in WAT (f) were examined on day 14 after these operations (d; n=6–7, f; n=5–9). The representative images derived from at least two experiments were displayed (a and b). Data are presented as means±s.d. *P<0.05, **P<0.01 by the unpaired t-test. NS, not significant.

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