Figure 3: Functional impact of the IL18RAP SNP rs2058660 genotypes.
From: Genome-wide analysis of the genetic regulation of gene expression in human neutrophils
A total of 19 donors were used for this experiment with n=7 for TT and n=9 for CC for the real time experiments. The gene expression of (a) CCL3 (b) CCL20 (c) TNF-α following treatment of neutrophils with IL-18 for 14 h, are displayed as a fold increase relative to unstimulated samples, with median and error bars for fold change of the respective gene expression values. P values shown are using a non-parametric Mann–Whitney test (d) CXCL8 levels measured by ELISA in the supernatant of the neutrophils cultured with IL-18 for 14 h. A total of 13 individuals was used for this experiment with n=4 for CC, n=6 for CT and n=3 for TT. The Kruskal–Wallis involving all groups was significant at P=0.001*. P values displayed in the figure D are pair wise Mann–Whitney test for each group between treated and untreated.
