Table 3 Specific list of genes with neutrophil eQTLs which also had a significant GWAS P value for an autoimmune condition.

From: Genome-wide analysis of the genetic regulation of gene expression in human neutrophils

Autoimmune/inflammatory condition

Neutrophil eQTLs

Crohn’s disease

CISD1*, IL18RAP*, TRPT1*, TUFM*, DNLZ, ERAP2, HLA-F, RNASET2, TFAM

Inflammatory bowel disease

CISD1*, HLA-DRB5*, TFAM, UTS2

Ulcerative colitis

HLA-DRB5*, LOC650557*, PIM3*, NFKB1, MANBA, UTS2

Rheumatoid arthritis

ARAP1*, CENTD2*, HLA-F, LOC253039, LY6G5C, RNASET2

Type 1 diabetes

HLA-DRB5*, HOXA5*, LOC650557*, SULT1A2*, TUFM*

Multiple sclerosis

CPT1B*, ECGF1, HLA-DRB5*, HLA-F, TYMP*, XRCC6BP1

Graves disease

HCG4*, HLA-F, RNASET2

Vitiligo

HCG4*, RNASET2

Systemic lupus Erythematosus

HLA-DRB5*, UBE2L3

Behcet's disease

CCR3*

Ankylosing spondylitis

CAST*

  1. eQTL, expression quantitative trait loci; GWAS, genome-wide association studies.
  2. Combining data from the neutrophil eQTLs identified with the GWAS catalogue variations for disease associations at GWAS threshold we found a significant enrichment for autoimmune and inflammatory disease. Refer to supplementary table 1 and supplementary online file 1 for comprehensive list.
  3. *refers to the neutrophil eQTLs not discovered in the B cells or monocytes.
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