Figure 6: MRI of spontaneous metastases in mice with orthotopic implant of 4T1–GFP-Luc2 breast cancer cells.
From: MRI detection of breast cancer micrometastases with a fibronectin-targeting contrast agent
(a) MRI and fluorescence cryo-imaging of cancer metastasis in mouse bearing metastasis, 40 days after cell inoculation in the mammary fat pad. (b) Representative sections showing whole-body co-registration of MRI and fluorescence cryo-images (arrows indicate metastases, auto-fluorescence from intestine and stomach is masked; Scale bars, 10 mm). (c) The co-registration quality of MRI and cryo-images. (d) Representative co-registered MRI (post-injected with the targeted contrast agent) and cryo-images of micrometastases in different organs or tissues (Scale bars, 1 mm).
