Figure 8: Histological analysis of whole-body cryo-images correlated with MRI.
From: MRI detection of breast cancer micrometastases with a fibronectin-targeting contrast agent
(a) Representative whole-body sections of haematoxylin and eosin staining, cryo-images and MR images of a metastasis-bearing mouse injected with CREKA-Cy5.0 and CREKA-Tris(Gd-DOTA)3 (Scale bar, 10 mm). Enlarged views of (b) a metastatic tumour in the lymph node (indicated by yellow rectangles in a) and (c) healthy muscle tissue (indicated by blue rectangles in a) (Scale bars, 1 mm). The (d) selected tumour and (e) healthy muscle areas were immunostained with an antibody against fibronectin (Scale bars, 100 μm).
