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On the dimerization of CCR5

Nature Immunology volume 6, page 535 (2005)Cite this article

To the editor:

In the February 2004 issue of Nature Immunology, Hernanz-Falcon et al. reported that the combination of two point mutations (I52V and V150A) in the first and fourth transmembrane domains of the CCR5 chemokine receptor disrupted its ability to form dimers, as shown by both biochemistry and resonance energy transfer–based approaches1. The authors also showed that the formation of oligomers of CCR5 is essential for triggering signaling but is dispensable for its correct expression on the cell surface and its ability to bind chemokines. The properties of this form of CCR5 (CCR5mut) offered unique perspectives regarding the mechanism and function of seven-transmembrane receptor dimerization. They were also of considerable interest for studies of human immunodeficiency virus 1 (HIV-1) cell entry, because CCR5 is the principal CD4-associated HIV-1 coreceptor, and dimerization has been proposed to modulate its activity2. The availability of CCR5mut therefore allowed us to address the coreceptor activity of a strictly monomeric form of CCR5.

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References

  1. Hernanz-Falcon, P. et al. Nat. Immunol. 5, 216–223 (2004).

    Article  CAS  Google Scholar 

  2. Brelot, A. & Alizon, M. AIDS 15, S3–11 (2001).

    Article  CAS  Google Scholar 

  3. Issafras, H. et al. J. Biol. Chem. 277, 34666–34673 (2002).

    Article  CAS  Google Scholar 

  4. Boute, N., Jockers, R. & Issad, T. Trends Pharmacol. Sci. 23, 351–354 (2002).

    Article  CAS  Google Scholar 

  5. Bulenger, S., Marullo, S. & Bouvier, M. Trends Pharmacol. Sci. 26, 131–137 (2005).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Cell Biology Department, Institut Cochin, Institut National de la Santé et de la Recherche Médicale U567, Centre National de la Recherche Scientifique UMR 8104, Paris, 75014, France

    Julie Lemay, Stefano Marullo, Ralf Jockers, Marc Alizon & Anne Brelot

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  1. Julie Lemay
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  2. Stefano Marullo
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  3. Ralf Jockers
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  4. Marc Alizon
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  5. Anne Brelot
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Correspondence to Marc Alizon.

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Lemay, J., Marullo, S., Jockers, R. et al. On the dimerization of CCR5. Nat Immunol 6, 535 (2005). https://doi.org/10.1038/ni0605-535a

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