During viral infections, antigen-presenting cells (APC) have traditionally been thought to recruit and activate CD4+ T cells by presenting fragments of viral proteins captured from the extracellular environment. A new study indicates that the material the APCs need to present is much closer: in fact, APCs need to make it themselves.
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Mintern, J., Villadangos, J. Antigen-presenting cells look within during influenza infection. Nat Med 21, 1123–1125 (2015). https://doi.org/10.1038/nm.3971
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DOI: https://doi.org/10.1038/nm.3971
