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Life after death: Controlling autoreactive CD8+ T-cell responses

Nature Medicine volume 7, pages 774–775 (2001)Cite this article

The uptake of apoptotic CD40L+ cells by immature dendritic cells leads to dendritic-cell activation. This mechanism might account for the generation of autoreactive CD8+ T cells in HIV infection and indicates a general mechanism for the regulation of autoimmune T-cell responses during infection. (pages 807–813)

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Figure 1: Apoptotic T cells regulate the development of autoreactive CD8+ T-cell responses.

Stephen Horwitz

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  1. University of Virginia Health Science Center Carter Immunology Center Departments of Pathology and Microbiology, Charlottesville, Virginia, USA

    Thomas J. Braciale

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  1. Thomas J. Braciale
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Braciale, T. Life after death: Controlling autoreactive CD8+ T-cell responses. Nat Med 7, 774–775 (2001). https://doi.org/10.1038/89886

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