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Reply to “Enzymatic/non-enzymatic formation of nitric oxide”

Nature Medicine volume 1, pages 1103–1104 (1995)Cite this article

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References

  1. Zweier, J.L., Wang, P., Samouilov, A. & Kuppusamy, P. Enzyme-independent formation of nitric oxide in biological tissues. Nature Med. 1, 804–809 (1995).

    Article  CAS  Google Scholar 

  2. Walters, C.L. & Taylor, A. McM. The reduction of nitrite by skeletal muscle mitochondria. Biochem. biaphys. Acta 96, 522–524 (1965).

    CAS  Google Scholar 

  3. Meyer, D.J. Interaction of cytochrome oxidases aa3 and d with nitrite. Nature New Biol. 245, 276–277 (1973).

    Article  CAS  Google Scholar 

  4. Brown, G.C. & Cooper, C.E. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett. 356, 295–298 (1994).

    Article  CAS  Google Scholar 

  5. Moncada, S., Palmer, R.M. Jr & Higgs, E.A. Nitric oxide: Physiology, pathophysiology and pharmacology. Pharm. Rev. 43, 109–142 (1991).

    CAS  PubMed  Google Scholar 

  6. Lai, C.S. & Komarov, A.M. Spin trapping of nitric oxide produced in vivo in septic-shock mice. FEBS Lett. 345, 120–124 (1994).

    Article  CAS  Google Scholar 

  7. Zweier, J.L., Wang, P. & Kuppusamy, P. Direct measurement of nitric oxide generation in the ischaemic heart using electron paramagnetic resonance spectroscopy. J. biol. Chem. 270, 304–307 (1995).

    Article  CAS  Google Scholar 

  8. Ambrosio, G. et al. Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischaemia and reflow. J. biol. Chem. 268, 18532–18541 (1993).

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Molecular and Cellular Biophysics Laboratories, Department of Medicine, Division of Cardiology and the Electron Paramagnetic Resonance Center, The Johns Hopkins Medical Institutions, 5501 Hopkins Bayview Circle, Baltimore, Maryland, 21224, USA

    Jay L. Zweier, Penghai Wang, Alexandre Samouilov & Periannan Kuppusamy

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  1. Jay L. Zweier
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  2. Penghai Wang
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  3. Alexandre Samouilov
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  4. Periannan Kuppusamy
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Zweier, J., Wang, P., Samouilov, A. et al. Reply to “Enzymatic/non-enzymatic formation of nitric oxide”. Nat Med 1, 1103–1104 (1995). https://doi.org/10.1038/nm1195-1103b

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