Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

West Nile virus: crossing the blood-brain barrier

Nature Medicine volume 10, pages 1294–1295 (2004)Cite this article

A study in mice traces the path of West Nile virus into the brain. Viral replication in peripheral tissues triggers a Toll-like receptor inflammatory response that alters the blood-brain barrier (pages 1366–1373).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: West Nile crossing.

Deborah Maizels

References

  1. Ballabh, P., Braun, A. & Nedergaard, M. Neurobiol. Dis. 16, 1–13 (2004).

    Article  CAS  Google Scholar 

  2. Wang, T. & Fikrig, E. Nat. Med. 10, 1366–1373 (2004).

    Article  CAS  Google Scholar 

  3. Granwehr, B.P. et al. Lancet Infect. Dis. 4, 547–556 (2004).

    Article  Google Scholar 

  4. Diamond, M.S., Shrestha, B., Mehlhop, E., Sitati, E. & Engle, M. Viral Immunol. 16, 259–278 (2003).

    Article  CAS  Google Scholar 

  5. Boehme, K.W. & Compton, T. J. Virol. 78, 7867–7873 (2004).

    Article  CAS  Google Scholar 

  6. Iwasaki, A. & Medzhitov, R. Nat. Immunol. 5, 987–995 (2004).

    CAS  PubMed  Google Scholar 

  7. de Vries, H.E. et al. J. Neuroimmunol. 64, 37–43 (1996).

    Article  CAS  Google Scholar 

  8. Fiala, M. et al. Mol. Med. 3, 553–564 (1997).

    Article  CAS  Google Scholar 

  9. Edelmann, K.H. et al. Virology 322, 231–238 (2004)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Medicine, Molecular Microbiology, Pathology & Immunology,

    Michael S Diamond & Robyn S Klein

  2. Departments of Medicine, Pathology & Immunology and Anatomy & Neurobiology, Washington University School of Medicine, St. Louis, 63110, Missouri, USA

    Michael S Diamond & Robyn S Klein

Authors
  1. Michael S Diamond
    View author publications

    Search author on:PubMed Google Scholar

  2. Robyn S Klein
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Diamond, M., Klein, R. West Nile virus: crossing the blood-brain barrier. Nat Med 10, 1294–1295 (2004). https://doi.org/10.1038/nm1204-1294

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/nm1204-1294

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing