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Malaria: A 21st century solution for an ancient disease

Abstract

The sequencing of the Plasmodium falciparum genome should reveal new parasite protein targets for drug and vaccine development.

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References

  1. Wirth, D.F. & Cattani, J. Winning the war against malaria. Tech. Rev. 100, 52–61 (1997).

    Google Scholar 

  2. Gardner, M.J. et al. Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Science 282, 1126– 1132 (1998).

    Article  CAS  Google Scholar 

  3. Weber, J.L. Interspersed repetitive DNA from Plasmodium falciparum. Molec. Biochem. Parasitol. 29, 117– 124 (1988).

    Article  CAS  Google Scholar 

  4. Wang, R. et al. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science 282, 476–480 (1998).

    Article  CAS  Google Scholar 

  5. DeRisi, J.L., Vishwanath, R.I. & Brown, P.O. Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 278, 680–686 (1997).

    Article  CAS  Google Scholar 

  6. Wodicka, L., Dong, H., Mittmann, M., Ming-Hsiu, H. & Lockhart, D.J. Genome-wide expression monitoring in Saccharomyces cerevisiae. Nat. Biotechnol. 15, 1359–1367 (1997).

    Article  CAS  Google Scholar 

  7. Velculescu, V.E. et al. Characterization of the yeast transcriptome. Cell 88, 243–251 (1997).

    Article  CAS  Google Scholar 

  8. Marton, M.J. et al. Drug target validation and identification of secondary drug target effects using DNA microarrays. Nature Med. 4, 1293–1301 (1998).

    Article  CAS  Google Scholar 

  9. Winzeler, E.A. et al. Direct allelic variation scanning of the yeast genome. Science 281, 1194–1197 (1998).

    Article  CAS  Google Scholar 

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Wirth, D. Malaria: A 21st century solution for an ancient disease. Nat Med 4, 1360–1362 (1998). https://doi.org/10.1038/3943

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