Abstract
Abnormal expression of microRNAs (miRNAs) in cancer suggests their applicability as diagnostic and prognostic signatures. Here we describe a new microarray platform, miRCURY™ LNA, based on Locked Nucleic Acid (LNA™)-modified capture probes that have uniquely high affinities for miRNAs. We applied this platform to study the global expression profiles of miRNAs in breast cancer with the aim of identifying potential new biomarkers.
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Acknowledgements
We thank the MAMBIO Group at Herlev University Hospital for kindly providing the tissues included in Figure 3.
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This article was submitted to Nature Methods by a commercial organization and has not been peer reviewed. Nature Methods takes no responsibility for the accuracy or otherwise of the information provided.
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Litman, T., Jacobsen, N., Nørholm, M. et al. MicroRNA profiling of breast cancer tissue using an LNA-based microarray. Nat Methods 4, i–ii (2007). https://doi.org/10.1038/nmeth1067
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DOI: https://doi.org/10.1038/nmeth1067
