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Does a stretch-inactivated cation channel integrate osmotic and peptidergic signals?

Nature Neuroscience volume 3, page 847 (2000)Cite this article

To the editor

In a recent paper in Nature Neuroscience, Chafke and Bourque1 assert that “mechanisms underlying osmoreception [in osmosensory neurons] are understood,” and more specifically, that a stretch-inactivated cation channel (SIC) is a point of “molecular convergence” for osmotransduction and peptide-induced excitation. An enticing idea, but the data do not stand up to scrutiny.

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Author information

Authors and Affiliations

  1. Physiology and Biophysical Sciences, 320 Cary Hall, SUNY, Buffalo, 14214, New York, USA

    Frederick Sachs

  2. Departments of Medicine and Biology, University of Ottawa, Ottawa Hospital, 725 Parkdale Avenue, Ottawa, K1Y 4K9, Ontario, Canada

    Catherine E. Morris

  3. Department of Physiology and Biophysics, University of Texas Medical Branch, 301 University Blvd., Galveston, 77555, Texas , USA

    Owen Hamill

Authors
  1. Frederick Sachs
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  2. Catherine E. Morris
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  3. Owen Hamill
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Sachs, F., Morris, C. & Hamill, O. Does a stretch-inactivated cation channel integrate osmotic and peptidergic signals?. Nat Neurosci 3, 847 (2000). https://doi.org/10.1038/78730

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