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Genetics

New molecular classification of gastric adenocarcinoma proposed by The Cancer Genome Atlas

Nature Reviews Clinical Oncology volume 11, page 499 (2014)Cite this article

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Currently, two histological classification systems are available to characterize gastric adenocarcinomas, which represents the majority of gastric tumours. The Lauren classification system comprises two subtypes (intestinal and diffuse) and the WHO classification has four subtypes (papillary, tubular, mucinous and poorly cohesive). Neither system is particularly clinically useful as their prognostic and predictive capabilities cannot adequately guide patient management. Now, The Cancer Genome Atlas research network has proposed a new classification scheme based on tumour molecular biology.

“There's a clear need for a more-refined genomic and molecular understanding of gastric cancer because it is one of the most common and treatment-refractory diseases,” explains lead investigator Adam Bass of the Dana–Farber Cancer Institute in Boston, USA. “To date, much of our efforts to develop new therapies have not had the benefit of robust systems to categorize the cancer and to identify key targets for individual patients.”

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References

  1. The Cancer Genome Atlas Research Network. Comprehensive molecular characterization of gastric adenocarcinoma. Nature 10.1038/nature13480

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Authors
  1. Mina Razzak
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Razzak, M. New molecular classification of gastric adenocarcinoma proposed by The Cancer Genome Atlas. Nat Rev Clin Oncol 11, 499 (2014). https://doi.org/10.1038/nrclinonc.2014.138

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