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Immunotherapy

Nice to see you — evolving MHC I–peptide presentation

Nature Reviews Clinical Oncology volume 15, page 5 (2018)Cite this article

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“The fact that few oncogenic mutations have been found to produce neoantigens in tumour samples obtained in the clinic led me to speculate that these early events might be subject to a strong immune selection during tumour initiation,” explains Joan Font-Burgada, corresponding author of the first study. In collaboration with Hannah Carter, Font-Burgada developed the Patient Harmonic-mean Best Rank (PHBR) score to predict the likelihood that a patient's MHC I variants will bind to a peptide sequence containing a particular residue. Low PHBR scores indicate a high likelihood of residue presentation. This scoring system was used to determine whether individual variations in HLA genotypes affect the ability to present a particular mutant peptide. The HLA-A, HLA-B and HLA-C allele-pair genotypes were assigned for 9,176 patients with cancer using mutational data available in The Cancer Genome Atlas (TCGA).

MHC I molecules influence tumour adaptation to the selective pressure of the immune system

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References

  1. Marty, R. et al. MHC-I genotype restricts the oncogenic mutational landscape. Cell http://dx.doi.org/10.1016/j.cell.2017.09.050 (2017)

  2. McGranahan, N. et al. Allele-specific HLA loss and immune escape in lung cancer evolution. Cell http://dx.doi.org/10.1016/j.cell.2017.10.001 (2017)

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  1. Diana Romero
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Romero, D. Nice to see you — evolving MHC I–peptide presentation. Nat Rev Clin Oncol 15, 5 (2018). https://doi.org/10.1038/nrclinonc.2017.180

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