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Nausea and vomiting

Getting to the root of the antiemetic effects of ginger

Nature Reviews Gastroenterology & Hepatology volume 10, page 259 (2013)Cite this article

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Studies have suggested that the antiemetic effect of ginger might be mediated via 5-HT3 receptors. Most work in this field has been conducted in cell lines or gut samples from mice. “With our work, we wanted to unravel the mode of action of ginger in the human system,” says Beate Niesler from the Department of Human Molecular Genetics, Institute of Human Genetics, Heidelberg, Germany. “It is well known that rodents differ from humans with regard to the 5-HT3 receptor system.”

Niesler and colleagues therefore used calcium influx assays and ligand binding studies to investigate the effect of ginger on homomeric 5-HT3A and heteromeric 5-HT3AB receptors in a human cell line (HEK293 cells) as well as in human submucous plexus material (in collaboration with Michael Schemann, Technical University, Munich, Germany).

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ORIGINAL RESEARCH PAPER

  1. Walstab, J. et al. Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-HT3 receptors of enteric neurons. Neurogastroenterol. Motil. doi:10.1111/nmo.12107

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  1. Isobel Leake
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Leake, I. Getting to the root of the antiemetic effects of ginger. Nat Rev Gastroenterol Hepatol 10, 259 (2013). https://doi.org/10.1038/nrgastro.2013.54

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