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Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. They include very small molecules, such as urea, and complex structures, such as Taxol. As they may only be isolable in small quantities, have interesting biological activity and chemical structures, natural product synthesis poses an interesting challenge in organic chemistry.
Homarine is a ubiquitous, phytoplankton-derived metabolite that is broken down by widely distributed and diverse marine bacteria containing a conserved homABCDER operon.
C-14 hydroxyl group is critical for the function of ent-kaurane diterpenoids (ent-KTs). Here, the authors report discovery and engineering of bacterial P450s for C-14 hydroxylation in ent-KTs.
Fire blight, caused by Erwinia amylovora, is a devastating disease threatening global apple and pear production. Here, the authors report a new antimicrobial compound from Pseudomonas soli that can effectively control fire blight pathogen in field conditions.
The discovery of seven soybean genes completes the biosynthetic pathway to major glyceollins, granting access to heterologous production and exploration of their antimicrobial potential.
