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New roles for TLR2

Nature Reviews Immunology volume 12, page 811 (2012)Cite this article

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indicating that the inflammatory reaction in gastric tumorigenesis was unaffected by Tlr2 ablation

The gp130F/F knock-in mouse model spontaneously develops intestinal-type gastric tumours at 6 weeks of age that are driven by interleukin-11 (IL-11)–signal transducer and activator of transcription 3 (STAT3) signalling. Gene expression profiling of tumours from these mice revealed that Tlr2 mRNA levels were significantly increased and that this was dependent on IL-11 signalling and STAT3 activation. Hyperactivated STAT3, upregulated IL-11 signalling and increased TLR2 expression were also observed in a second transgenic mouse model of gastric cancer and in samples of human gastric cancer, indicating that these factors are important in gastric tumorigenesis. Furthermore, patients with STAT3hi TLR2hi gastric tumours had reduced overall survival in comparison to those with STAT3lowTLR2low tumours.

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ORIGINAL RESEARCH PAPER

  1. Tye, H. et al. STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation. Cancer Cell 22, 466–478 (2012)

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  1. Senior Editor, Nature Reviews Cancer,

    Gemma K. Alderton

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  1. Gemma K. Alderton
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This article is modified from the original in Nature Rev. Cancer (doi:10.1038/nrc3407).

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Alderton, G. New roles for TLR2. Nat Rev Immunol 12, 811 (2012). https://doi.org/10.1038/nri3351

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