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Signalling

BCL-6 curbs glycolysis

Nature Reviews Immunology volume 14, page 651 (2014)Cite this article

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One of the many roles of BCL-6 is in promoting the development of memory cells from both CD4+ and CD8+ effector T cells. High environmental concentrations of interleukin-2 (IL-2) reduce BCL-6 expression, whereas low concentrations of IL-2 promote BCL-6 expression. In addition, high levels of IL-2 promote the expression of genes encoding glycolytic molecules. But are these two pathways functionally linked and if so, how?

BCL-6 was shown to dominantly repress the promoter activity and expression of key glycolytic genes

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References

  1. Oestreich, K. J. et al. Bcl-6 directly represses the gene program of the glycolysis pathway. Nature Immunol. http://dx.doi.org/10.1038/ni.2985 (2014)

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  1. Olive Leavy
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Pollizzi, K. N. & Powell, J. D. Integrating canonical and metabolic signalling programmes in the regulation of T cell responses. Nature Rev. Immunol. 14, 435–446 (2014)

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Leavy, O. BCL-6 curbs glycolysis. Nat Rev Immunol 14, 651 (2014). https://doi.org/10.1038/nri3749

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