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Organ grinder not monkey?

Nature Reviews Molecular Cell Biology volume 4, page 430 (2003)Cite this article

B. subtilis is a well-characterized model system for differentiation and programmed cell-specific gene expression. During sporulation in Bacillus, two cell-types form: the mother cell and the forespore, which is destined to become a spore. Without the SpoOA response-regulator, sporulation doesn't occur.

A complex phosphorelay integrates metabolic, environmental and cell-cycle cues to activate SpoOA. Phosphorylated SpoOA activates the transcription of sporulation genes, which tips the balance so that sporulation occurs. So, as in eukaryotes, phosphorylation of key proteins regulates cell-cycle progression.

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ORIGINAL RESEARCH PAPER

  1. Fujita, M. & Losick, R. The master regulator for entry into sporulation in Bacillus subtilis becomes a cell-specific transcription factor after asymmetric division. Genes Dev. 17, 1166–1174 (2003)

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  1. Associate Editor, Nature Reviews Microbiology,

    Susan Jones

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  1. Susan Jones
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Jones, S. Organ grinder not monkey?. Nat Rev Mol Cell Biol 4, 430 (2003). https://doi.org/10.1038/nrm1144

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  • DOI: https://doi.org/10.1038/nrm1144

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