Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • In Brief
  • Published:

Translation

Lessons in maturation

Nature Reviews Molecular Cell Biology volume 13, page 478 (2012)Cite this article

Subjects

Two groups provide insights into quality control during ribosome biogenesis, showing that maturation of the pre-40S ribosomal subunit actually requires association with both the 60S subunit and the translation initiation factor eIF5B. A late step in 40S maturation requires the cleavage of 20S pre-ribosomal RNA (rRNA) to mature 18S rRNA by the endonuclease Nob1. Lebaron et al. show that Nob1-mediated cleavage of the 20S pre-rRNA is regulated by pre-rRNA association of Fun12, the yeast homologue of eIF5B. The 60S ribosomal subunit also associates with pre-40S particles, and the authors propose that this is a trigger for Nob1-mediated cleavage. In the second study, Strunk et al. also find that eIF5B promotes association of the 60S subunit with the pre-40S particle, to form an 80S-like particle. However, these are not functional as they lack mRNA and initiator tRNA. The translation termination factor Rli1 is required to dissociate such non-functional complexes and drive formation of a mature ribosome.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

ORIGINAL RESEARCH PAPERS

  1. Lebaron, S. et al. Proofreading of pre-40S ribosome maturation by a translation initiation factor and 60S subunits. Nature Struct. Mol. Biol. 1 Jul 2012 (doi:10.1038/nsmb.2308

  2. Strunk, B. S. et al. A translation-like cycle is a quality control checkpoint for maturing 40S ribosome subunits. Cell 150, 111–121 (2012) Article

    Article  CAS  Google Scholar 

Download references

Authors
  1. Alison Schuldt
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schuldt, A. Lessons in maturation. Nat Rev Mol Cell Biol 13, 478 (2012). https://doi.org/10.1038/nrm3405

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrm3405

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing